Two-Minute CycleACLS exam prepGet the app

ACLS · Algorithms · 2025 Guidelines

ACLS algorithms, explained the way the exam tests them

The core ACLS algorithms are six flowcharts: cardiac arrest, post-arrest care, bradycardia, tachycardia, ACS and stroke, all set by the 2025 AHA Guidelines for CPR and Emergency Cardiovascular Care (October 22, 2025). Run the 24 cards; each chart below explains a miss.

24 algorithm cards

  1. Card 01 / 24Cardiac arrest

    Which statement about fluid resuscitation during cardiac arrest is correct?

    Explanation

    Keyed answerB. Fluid boluses should be administered when hypovolemia is suspected as a cause

    Your pick

    During cardiac arrest, routine fluid boluses are not recommended unless hypovolemia is suspected as a cause of the arrest. In cases where hypovolemia is a suspected cause, rapid infusion of isotonic crystalloid solution is appropriate to restore intravascular volume.

  2. Card 02 / 24Brady & tachy

    In ACLS protocols, why is it important to identify reversible causes of bradyarrhythmia such as hyperkalemia?

    Explanation

    Keyed answerB. It allows correction of the underlying condition without invasive procedures

    Your pick

    Identifying reversible causes allows clinicians to correct the underlying abnormality, potentially resolving the bradyarrhythmia without the need for invasive interventions like pacing.

  3. Card 03 / 24Cardiac arrest

    Why is the administration of AV nodal blocking agents contraindicated in atrial fibrillation with rapid ventricular response in Wolff-Parkinson-White syndrome?

    Explanation

    Keyed answerA. They may promote conduction via the accessory pathway, increasing risk of ventricular fibrillation

    Your pick

    AV nodal blockers can preferentially block the conduction through the normal AV node, thereby promoting conduction through the accessory pathway, which may precipitate a dangerous ventricular arrhythmia.

  4. Card 04 / 24Brady & tachy

    In an elderly patient with bradycardia and a prolonged PR interval, what additional diagnostic modality can help uncover intermittent high-grade AV block?

    Explanation

    Keyed answerD. Holter monitoring

    Your pick

    Holter monitoring provides continuous ECG recording over an extended period, which can reveal intermittent episodes of high-grade AV block not seen on a single ECG.

  5. Card 05 / 24Cardiac arrest

    Within the context of ACLS, when should antiarrhythmic agents like amiodarone be administered?

    Explanation

    Keyed answerD. After defibrillation and epinephrine in refractory shockable rhythms.

    Your pick

    They are indicated after defibrillation and epinephrine in refractory shockable rhythms, according to ACLS protocols.

  6. Card 06 / 24Brady & tachy

    Which of the following is the most appropriate pharmacological treatment for hemodynamically stable atrial fibrillation with rapid ventricular response in a patient with preserved ejection fraction?

    Explanation

    Keyed answerB. Metoprolol

    Your pick

    For stable atrial fibrillation with rapid ventricular response in patients with preserved ejection fraction, a beta-blocker like metoprolol is recommended to control the ventricular rate.

  7. Card 07 / 24Cardiac arrest

    How does integrating pharmacologic strategies with timely defibrillation optimize outcomes in refractory ventricular arrhythmias?

    Explanation

    Keyed answerD. Timely medication administration combined with defibrillation helps terminate refractory arrhythmias.

    Your pick

    Sequential and coordinated interventions increase the likelihood of rhythm conversion by addressing both the electrical and biochemical aspects of arrest.

  8. Card 08 / 24Brady & tachy

    Which medication would be most appropriate for chemical cardioversion of new-onset atrial fibrillation in a patient with hypertrophic cardiomyopathy?

    Explanation

    Keyed answerB. Amiodarone

    Your pick

    Amiodarone is the preferred agent for chemical cardioversion in patients with hypertrophic cardiomyopathy as it has less negative inotropic effect compared to other antiarrhythmics. It also avoids the potential for increased outflow tract obstruction that can occur with some other agents.

  9. Card 09 / 24Cardiac arrest

    Which of the following is a 'H' in the 'Hs and Ts' of potentially reversible causes of cardiac arrest?

    Explanation

    Keyed answerB. Hypovolemia

    Your pick

    Hypovolemia is one of the 'H's in the 'Hs and Ts' mnemonic for potentially reversible causes of cardiac arrest. The 'H's include Hypovolemia, Hypoxia, Hydrogen ion (acidosis), Hypo/Hyperkalemia, and Hypothermia.

  10. Card 10 / 24Brady & tachy

    What is the maximum total dose of atropine recommended for treating bradycardia in adults?

    Explanation

    Keyed answerC. 3 mg

    Your pick

    The maximum total dose of atropine for treating bradycardia in adults is 3 mg. Doses above this level are unlikely to produce additional beneficial chronotropic effects.

  11. Card 11 / 24Cardiac arrest

    What is the recommended dose of calcium chloride for a patient with hyperkalemia-induced cardiac arrest?

    Explanation

    Keyed answerA. 10 mL of 10% solution (1 gram) IV/IO

    Your pick

    When calcium chloride is given for suspected hyperkalemia in cardiac arrest, the usual dose is 10 mL of a 10% solution (1 gram) IV/IO; calcium antagonizes the cardiac effects of a high potassium. Note that the 2025 AHA Guidelines describe the effectiveness of calcium in hyperkalemic cardiac arrest as not well established, and routine calcium in arrest is not recommended. High-quality CPR, defibrillation when indicated and treating the cause come first.

  12. Card 12 / 24Brady & tachy

    What is the appropriate initial management for a 68-year-old patient presenting with new onset atrial fibrillation with a ventricular rate of 160 bpm and normal blood pressure?

    Explanation

    Keyed answerC. Rate control with IV diltiazem or metoprolol

    Your pick

    For a hemodynamically stable patient with new-onset atrial fibrillation and rapid ventricular response, the initial approach is rate control with AV nodal blocking agents. IV diltiazem or beta-blockers like metoprolol are appropriate first-line medications to slow the ventricular rate.

  13. Card 13 / 24Cardiac arrest

    Which antiarrhythmic medication is recommended for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia after the third shock?

    Explanation

    Keyed answerD. Amiodarone 300 mg IV/IO

    Your pick

    Amiodarone is the recommended antiarrhythmic medication for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia. The initial dose is 300 mg IV/IO bolus, with a second dose of 150 mg if needed.

  14. Card 14 / 24Brady & tachy

    Which finding on a 12-lead ECG best differentiates atrial flutter from other supraventricular tachycardias?

    Explanation

    Keyed answerC. Saw-tooth flutter waves in leads II, III, and aVF

    Your pick

    Atrial flutter typically presents with characteristic saw-tooth flutter waves (F waves) in the inferior leads (II, III, aVF), which represent rapid regular atrial activity at a rate of 250-350 bpm. This distinctive pattern helps differentiate atrial flutter from other supraventricular tachycardias.

  15. Card 15 / 24Cardiac arrest

    What is a key consideration when interpreting end-tidal CO2 (ETCO2) values during cardiac arrest?

    Explanation

    Keyed answerC. Persistently low values often indicate poor cardiac output from inadequate CPR quality

    Your pick

    Persistently low ETCO2 during CPR usually means little blood is reaching the lungs, which most often points to poor compression quality. ETCO2 works as a real-time marker of CPR effectiveness: better compressions should raise it, and an abrupt, sustained rise can be a sign of return of spontaneous circulation (ROSC). The 2025 chart shows the trend without a number; the Guidelines text treats at least 10 mm Hg, ideally 20, as a sign the compressions are working.

  16. Card 16 / 24Brady & tachy

    What is the most appropriate initial management for a patient with a narrow-complex tachycardia at 170 bpm who is complaining of mild palpitations but has stable vital signs?

    Explanation

    Keyed answerD. Vagal maneuvers (e.g., Valsalva)

    Your pick

    For stable patients with narrow-complex tachycardia, vagal maneuvers are the recommended first step in management before proceeding to pharmacological interventions. These non-invasive techniques may terminate the arrhythmia by increasing parasympathetic tone.

  17. Card 17 / 24Cardiac arrest

    Which of the following is the correct dose of sodium bicarbonate for a patient with prolonged cardiac arrest and suspected metabolic acidosis?

    Explanation

    Keyed answerC. 1 mEq/kg IV

    Your pick

    For patients with prolonged cardiac arrest and suspected metabolic acidosis, sodium bicarbonate can be considered at a dose of 1 mEq/kg IV. It is not routinely recommended in cardiac arrest but may be considered in specific situations like known preexisting hyperkalemia, tricyclic antidepressant overdose, or prolonged resuscitation with severe acidosis.

  18. Card 18 / 24Brady & tachy

    Which of the following medications can potentially exacerbate bradycardia and should be considered as a possible cause in patients presenting with symptomatic bradycardia?

    Explanation

    Keyed answerA. Beta-blockers (e.g., metoprolol)

    Your pick

    Beta-blockers like metoprolol can cause or exacerbate bradycardia by blocking beta-adrenergic receptors in the heart, reducing the influence of sympathetic stimulation on heart rate and conduction. Identifying and holding these medications is an important part of bradycardia management.

  19. Card 19 / 24Cardiac arrest

    What is the maximum number of defibrillation attempts recommended before initiating CPR in witnessed VF cardiac arrest?

    Explanation

    Keyed answerB. One defibrillation attempt

    Your pick

    In witnessed VF cardiac arrest, one immediate defibrillation attempt is recommended before initiating CPR. After the initial shock, CPR should be performed for 2 minutes before reassessing the rhythm and potentially delivering additional shocks.

  20. Card 20 / 24Brady & tachy

    Which medication should be considered for rate control in atrial fibrillation for a patient with decompensated heart failure?

    Explanation

    Keyed answerD. Digoxin

    Your pick

    Digoxin is appropriate for rate control in atrial fibrillation in patients with decompensated heart failure as it doesn't have the negative inotropic effects that many other rate-controlling agents have, though its onset is slower than other options.

  21. Card 21 / 24Cardiac arrest

    When should the first shock be delivered to a cardiac arrest victim found in a shockable rhythm?

    Explanation

    Keyed answerA. As soon as the AED/defibrillator is ready

    Your pick

    The first shock should be delivered as soon as the AED or defibrillator is ready. Early defibrillation for shockable rhythms is critical for survival, as the chances of successful defibrillation decrease with time.

  22. Card 22 / 24Brady & tachy

    Which of the following is a correct pairing of bradyarrhythmia and its appropriate pharmacological treatment?

    Explanation

    Keyed answerA. Symptomatic sinus bradycardia — Atropine

    Your pick

    Symptomatic sinus bradycardia is appropriately treated with atropine, which blocks parasympathetic (vagal) effects on the SA node, increasing the heart rate. Atropine is the first-line pharmacological treatment for symptomatic bradycardia according to ACLS guidelines.

  23. Card 23 / 24Cardiac arrest

    According to ACLS guidelines, what is the recommended approach for a patient with refractory VF/pVT after standard treatment?

    Explanation

    Keyed answerC. Consider advanced interventions such as double sequential defibrillation, ECPR, or emergent PCI if available

    Your pick

    For VF/pVT that persists after standard treatment (defibrillation, CPR, epinephrine and an antiarrhythmic), the 2025 Guidelines say the usefulness of double sequential or vector-change defibrillation is not established, so it may be considered but is not routine; extracorporeal CPR (ECPR) where available and PCI for a suspected cardiac cause are the other options. Escalating epinephrine, stopping after three shocks and routine thoracotomy are not part of the algorithm.

  24. Card 24 / 24Brady & tachy

    A 45-year-old patient presents with sudden onset of regular narrow-complex tachycardia at 220 bpm. After two doses of adenosine failed to convert the rhythm, what is the most appropriate next step?

    Explanation

    Keyed answerA. Administer IV diltiazem

    Your pick

    After failed adenosine attempts for narrow-complex tachycardia, the next step is typically a longer-acting AV nodal blocking agent or an antiarrhythmic medication. IV diltiazem is appropriate for ongoing rate control in a hemodynamically stable patient with SVT that was refractory to adenosine.

  25. Score card

    0%

    Answer a few cards and come back to this one.

    • Cardiac arrestnot yet
    • Brady & tachynot yet

    The thin line on each bar marks 84%, the written-exam pass mark AHA Training Centers usually quote; your instructor confirms the exact rule.

Pick an answer and the card turns over to the explanation. Keys: A to D or 1 to 4, arrows to move, F to turn the card.

Map

The six ACLS algorithms and how the exam uses them

The ACLS Provider Course was updated to the 2025 Guidelines when they were released, and Training Centers had to teach from the new materials by March 1, 2026. So the charts the exam uses now are the 2025 set. They read as one system: every algorithm opens with a single question, and the answer sends you down one lane.

The six ACLS algorithms at a glance
AlgorithmWhere it startsThe question that splits itFirst moves
Cardiac arrestNo pulse, not breathing normallyShockable rhythm or not?CPR, then a shock or epinephrine
Post-cardiac arrest careReturn of spontaneous circulation (ROSC)Following commands?Airway, oxygen, blood pressure, 12-lead
BradycardiaPulse, rate typically under 50/minCardiopulmonary compromise?Atropine, then pacing or an infusion
TachycardiaPulse, rate typically 150/min or moreUnstable? Then: wide QRS?Synchronized cardioversion or drugs
Acute coronary syndromesChest pain or another ischemic pictureWhat does the 12-lead show?Aspirin, 12-lead inside 10 minutes
Suspected strokeSudden neuro deficitBleed on the scan?Last known normal, glucose, imaging

The written exam drops you into the middle of a chart (third shock given, rhythm still VF: what now?) and asks for the next box. The Megacode asks for the same thing out loud, as orders to a team. Learn the splitting questions first; the boxes hang off them.

VF/pVT

Adult cardiac arrest algorithm: VF and pulseless VT

The ACLS cardiac arrest algorithm is one chart with two lanes. After CPR starts and the pads go on, the only question is whether the rhythm is shockable. VF and pulseless VT go to the shock lane; asystole and PEA go to the drug lane. Both lanes run in 2-minute cycles of CPR with a rhythm check at the end of each, and both carry epinephrine 1 mg every 3–5 minutes.

Cardiac arrest

  1. Start CPR. Bag-mask ventilation with oxygen, attach the monitor/defibrillator.
  2. Rhythm shockable?

    Yes: VF or pVT

    1. Shock
    2. CPR 2 min · IV access (IO if IV fails)
    3. Shock if still VF/pVT
    4. CPR 2 min · epinephrine 1 mg every 3–5 min · consider advanced airway, capnography
    5. Shock if still VF/pVT
    6. CPR 2 min · amiodarone or lidocaine · treat reversible causes
    7. Rhythm check every 2 min. Still shockable: shock and keep cycling.

    No: asystole or PEA

    1. Epinephrine 1 mg as soon as possible
    2. CPR 2 min · IV/IO access · epinephrine every 3–5 min · consider advanced airway
    3. Look for and treat the reversible causes
    4. Rhythm check every 2 min. Turned shockable: cross to the shock lane.
  3. Signs of ROSC: go to post-cardiac arrest care
Adult cardiac arrest, drawn as two lanes from one rhythm check (2025 Guidelines)

ACLS shockable rhythms

Ventricular fibrillation
Monomorphic ventricular tachycardia

Only two rhythms take a shock in arrest: ventricular fibrillation and pulseless ventricular tachycardia. Polymorphic VT without a pulse is treated as VF. Asystole and pulseless electrical activity (PEA) are never shocked, however chaotic the room feels.

The VF/pVT lane, shock by shock

  1. 01First shock

    Shock as soon as the defibrillator is ready, then straight back on the chest for 2 minutes. No pulse check right after the shock.

  2. 02Second shock

    Still VF or pVT at the rhythm check: shock, resume CPR, give the first epinephrine during that cycle. Access is IV first in 2025; intraosseous is the backup.

  3. 03Third shock

    Still shockable: shock again, then amiodarone 300 mg (or lidocaine). The second amiodarone dose, 150 mg, comes on a later cycle if VF persists.

  4. 04Every cycle after

    Shock, 2 minutes of CPR, epinephrine every 3–5 minutes, and a working list of reversible causes (the H’s and T’s).

Drugs and energies on the 2025 adult cardiac arrest chart
On the arrest chartDoseWhen
Epinephrine1 mg IV/IOEvery 3–5 min. Non-shockable: as soon as possible. Shockable: after the second shock
Amiodarone300 mg bolus, then 150 mgShock-refractory VF/pVT, around the third shock
Lidocaine (instead of amiodarone)1–1.5 mg/kg, then 0.5–0.75 mg/kgSame slot as amiodarone
Biphasic shockManufacturer's dose (for example 120–200 J); unknown: maximumLater shocks at least equivalent; higher may be considered
Monophasic shock360 JEvery shock

The numbers behind high-quality CPR

CPR quality the chart assumes

Rate
100–120 compressions/min
Depth
At least 2 inches (5 cm), full recoil
No advanced airway
30:2
Advanced airway
1 breath every 6 seconds (10/min), compressions continuous
Breath size
Visible chest rise: roughly a third to a half of an adult bag
Compressor swap
Every 2 min, sooner if tired
Capnography
ETCO₂ low or falling: fix CPR quality first

Most people revise the drug doses and skim these numbers, which is understandable and backwards: almost every arrest question assumes good compressions. If ETCO₂ is low or drifting down, the next step is better CPR, not another drug.

PEA

Asystole and PEA: the non-shockable lane

The ACLS algorithm for asystole and the ACLS algorithm for PEA are the same lane: CPR, epinephrine 1 mg as soon as possible, and a search for the reversible cause. Nothing in this lane is shocked, and there is no antiarrhythmic in it.

Asystole

Asystole / PEA

  1. Pulseless, rhythm not shockable: asystole or an organized rhythm without a pulse (PEA)
  2. Epinephrine 1 mg IV/IO as soon as possible, then every 3–5 min
  3. CPR in 2-min cycles · consider advanced airway and waveform capnography
  4. Hunt the cause: hypovolemia, hypoxia, acidosis, potassium, hypothermia, tension pneumothorax, tamponade, toxins, pulmonary or coronary thrombosis
  5. Rhythm at the 2-min check?

    Shockable

    1. Shock, then follow the VF/pVT lane

    Not shockable

    1. Back to CPR and epinephrine; keep treating the cause

    Organized rhythm

    1. Check a pulse. Pulse present: post-cardiac arrest care
The non-shockable lane of the adult cardiac arrest algorithm

PEA is the rhythm the exam uses to test causes. A monitor showing a tidy narrow-complex rhythm with no pulse means the electricity is fine and something mechanical or metabolic is not: empty tank, tension, tamponade, a clot, potassium. The stem usually hides the cause in one clue (a dialysis patient, a trauma, an opioid overdose), and the right answer treats it.

The ten causes, with the stem clue for each, are on the H’s and T’s page, which has its own 8-card deck.

ROSC

Post-cardiac arrest care algorithm

The post cardiac arrest algorithm starts the moment a pulse comes back and works top to bottom: airway, oxygen and ventilation, blood pressure, a 12-lead, then a single question about the brain. If the patient is not following commands, temperature control, EEG and delayed prognosis follow.

Post-arrest

  1. ROSC obtained
  2. Airway: place or exchange an advanced airway as needed; confirm with waveform capnography
  3. Oxygen and ventilation: 100% oxygen until SpO₂ reads reliably, then SpO₂ 90–98%; PaCO₂ 35–45 mm Hg
  4. Blood pressure: fluids and vasopressors to keep MAP ≥65 mm Hg
  5. Early tests: 12-lead ECG; consider CT and/or ultrasound to find the cause
  6. Following commands (off sedation)?

    Yes

    1. Ongoing critical care; coronary angiography when appropriate

    No or unsure

    1. Deliberate temperature control, 32–37.5 °C
    2. EEG for seizures · coronary angiography when appropriate
    3. Prognosis: multimodal, no earlier than 72 h
Adult post-cardiac arrest care after ROSC (2025 Guidelines)

Post-ROSC targets, 2025

SpO₂
90–98% (PaO₂ 60–105 mm Hg)
PaCO₂
35–45 mm Hg, unless severe acidemia
MAP
At least 65 mm Hg
Temperature
One constant target, 32–37.5 °C, for at least 36 hours if not following commands
Glucose
Avoid under 70 mg/dL and over 180 mg/dL
Prognosis
Delayed: 72 hours or more after ROSC or normothermia

Three things moved in 2025, and old flashcards still carry the earlier versions. The oxygen saturation target now starts at 90%, not 92%. Temperature control is held for at least 36 hours, up from 24. And head-to-pelvis CT and point-of-care ultrasound after ROSC are now named as reasonable, to find the cause and any injury from the resuscitation.

ST elevation on the post-ROSC 12-lead, cardiogenic shock or recurrent VF/VT point to emergency coronary angiography. That cue appears in Megacode cases as often as on the written test.

Brady

ACLS bradycardia algorithm

The ACLS bradycardia algorithm turns on symptoms, not on the number. A heart rate typically under 50/min matters only when it causes cardiopulmonary compromise: hypotension, acutely altered mental status, signs of shock, ischemic chest discomfort or acute heart failure. Without those, you support, monitor and look for the cause.

Sinus bradycardia
Third-degree (complete) AV block

Bradycardia

  1. Heart rate typically under 50/min and too slow for the clinical picture
  2. Support: airway, oxygen if needed, monitor, 12-lead, IV access; look for the cause
  3. Cardiopulmonary compromise? Hypotension, altered mental status, shock, ischemic chest discomfort, acute heart failure

    No

    1. Monitor and observe; treat the cause

    Yes

    1. Atropine 1 mg IV, repeat every 3–5 min, maximum 3 mg
    2. Atropine ineffective?

      Yes

      1. Transcutaneous pacing and/or dopamine 5–20 mcg/kg/min or epinephrine 2–10 mcg/min
      2. Expert consultation; transvenous pacing
Adult bradycardia with a pulse (2025 Guidelines)
ACLS brady algorithm doses, with the outdated values to unlearn
Brady step2025 doseOld number still in circulation
Atropine1 mg IV bolus, every 3–5 min, max 3 mg0.5 mg (pre-2020)
Dopamine infusion5–20 mcg/kg per minute, titrated; taper slowly2–20 mcg/kg per minute
Epinephrine infusion2–10 mcg per minute, titratedunchanged
Transcutaneous pacingIf atropine is ineffective, alongside or instead of an infusionunchanged

Causes the chart lists: myocardial ischemia or infarction, drugs (calcium-channel blockers, beta-blockers, digoxin), hypoxia and electrolyte problems such as hyperkalemia. A stem that mentions a new beta-blocker is pointing at one of them.

Tachy

ACLS tachycardia algorithm: tachyarrhythmia with a pulse

The ACLS tachycardia algorithm, called the tachyarrhythmia with a pulse algorithm in the 2025 set, asks two questions in a fixed order. First: is this patient unstable because of the rate? If yes, synchronized cardioversion. If no: is the QRS wide (0.12 s or more) or narrow? That second answer picks the drugs.

Tachycardia

  1. Heart rate typically 150/min or more · airway, oxygen if hypoxemic, monitor, IV, 12-lead
  2. Unstable? Hypotension, altered mental status, shock, ischemic chest discomfort, acute heart failure

    Yes: unstable

    1. Synchronized cardioversion, sedate whenever feasible
    2. Regular narrow complex: adenosine may be tried while you prepare

    No: stable

    1. QRS 0.12 s or wider?

      Wide

      1. Adenosine only if regular and monomorphic · procainamide or amiodarone infusion · expert consultation

      Narrow

      1. Vagal maneuvers and adenosine (if regular) · beta-blocker or calcium-channel blocker
Adult tachyarrhythmia with a pulse (2025 Guidelines)

ACLS SVT: the narrow, regular rhythm

Supraventricular tachycardia

The 2025 chart says narrow-complex tachycardia where older ones said SVT; the treatment ladder is the same. Stable: vagal maneuvers, then adenosine 6 mg, then 12 mg, then a beta-blocker or a calcium-channel blocker. Unstable: synchronized cardioversion, with adenosine as an option only while the pads go on.

The ACLS afib algorithm runs through the same chart

Atrial fibrillation

There is no separate AF chart. Unstable atrial fibrillation gets synchronized cardioversion at 200 J or more; stable AF with a fast response gets rate control with a beta-blocker or a calcium-channel blocker. AF is irregular, so adenosine has no place in it. When the stem adds a pre-excitation history (Wolff-Parkinson-White), AV-nodal blockers become the wrong answer and expert help the right one.

Starting energies on the 2025 tachycardia chart (biphasic; your device's recommendation comes first)
RhythmFirst synchronized shockNote
Narrow-complex tachycardia100 JRegular SVT that is unstable
Monomorphic VT with a pulse100 JRegular, wide and monomorphic
Atrial fibrillationAt least 200 JRaised for 2025; escalate if it fails
Atrial flutter200 JEscalate if it fails
Polymorphic VTDefibrillation dose, not synchronizedThe monitor cannot sync to it

Stable-tachycardia drugs, 2025 chart

Adenosine
6 mg rapid IV push with a saline flush; 12 mg if needed
Procainamide
20–50 mg/min until the rhythm breaks, hypotension, QRS widens over 50% or 17 mg/kg; avoid with long QT or heart failure
Amiodarone
150 mg over 10 min, repeat if VT recurs; then 1 mg/min for the first 6 hours

Wide and polymorphic: the shock that must not be synchronized

Torsades de pointes

Torsades and other polymorphic VT get the defibrillation dose, unsynchronized, the moment they cause instability. Sotalol is no longer on the 2025 chart; for stable monomorphic VT the infusions are procainamide or amiodarone.

ACS

Acute coronary syndromes algorithm

The ACLS acute coronary syndrome algorithm is a clock with an ECG in the middle. Aspirin and a 12-lead come first; the 12-lead sorts the patient into STEMI, high-risk NSTE-ACS or low-risk chest pain, and each lane has its own pace.

ACS

  1. Symptoms suggest ischemia or infarction
  2. Aspirin 162–325 mg · oxygen only if SpO₂ under 90% · nitroglycerin · morphine or fentanyl if pain persists
  3. 12-lead ECG acquired and read within 10 min of first medical contact
  4. What does the 12-lead show?

    ST elevation

    1. STEMI: reperfusion if onset ≤12 h · PCI within 90 min of first contact, or fibrinolysis within 30 min of arrival

    ST depression or dynamic T waves

    1. High-risk NSTE-ACS: risk score (TIMI or GRACE); early invasive strategy if troponin rises or risk is high

    Normal or nondiagnostic

    1. Low or intermediate risk: monitor, serial ECGs and troponin
Acute coronary syndromes, from first contact to reperfusion (2025 Guidelines)
The time goals on the ACS chart
ACS clockGoal
12-lead ECGWithin 10 minutes of first medical contact
Primary PCI (STEMI)First medical contact to balloon 90 minutes or less
Fibrinolysis (STEMI, no timely PCI)Door to needle 30 minutes
Portable chest X-rayWithin 30 minutes, never delaying the cath lab

The 2025 chart dropped left bundle branch block as a definite STEMI equivalent, no longer names clopidogrel as the main antiplatelet, adds fentanyl beside morphine, and lists enoxaparin, fondaparinux and ACE inhibitors among the adjunctive drugs.

Stroke

ACLS algorithm for stroke

The ACLS algorithm for stroke is about time and one scan. Establish when the patient was last known normal, check glucose, get brain imaging fast, and let the scan decide: bleed or no bleed. No bleed opens the reperfusion lanes.

Stroke

  1. Stroke signs: activate the stroke protocol; note the time last known normal; check glucose
  2. Prehospital notification; on arrival straight to the brain imaging suite; NIH Stroke Scale
  3. Hemorrhage on CT or MRI?

    Yes

    1. Intracranial hemorrhage protocol

    No

    1. Thrombolytic candidate: alteplase or tenecteplase
    2. CTA (CT perfusion as indicated): large-vessel occlusion → endovascular therapy
  4. Stroke unit or neurological ICU
Adult suspected stroke, from first sign to reperfusion (2025 Guidelines)

Stroke times the exam uses

Brain imaging
Within 20 minutes of arrival
IV thrombolysis
Standard window 4.5 hours from last known normal
Endovascular therapy
Selected patients up to 24 hours from last known normal
Drugs
Alteplase, or tenecteplase (added to the ACLS chart in 2025)

Doses

ACLS medication algorithm: every dose on one table

The ACLS medication algorithm is not a separate chart; it is the doses printed beside each flowchart. Here they are on one table, the way you would tab them in an open-resource exam.

Every dose and energy on the 2025 adult ACLS charts
Drug or energy2025 doseWhere it belongs
Epinephrine (arrest)1 mg IV/IO every 3–5 minCardiac arrest, both lanes
Amiodarone (arrest)300 mg bolus, then 150 mgShock-refractory VF/pVT
Lidocaine (arrest)1–1.5 mg/kg, then 0.5–0.75 mg/kgAlternative to amiodarone
Atropine1 mg every 3–5 min, max 3 mgSymptomatic bradycardia
Dopamine infusion5–20 mcg/kg per minuteBradycardia, atropine ineffective
Epinephrine infusion2–10 mcg per minuteBradycardia, atropine ineffective
Adenosine6 mg rapid push, then 12 mgRegular narrow (or regular monomorphic wide) tachycardia
Procainamide20–50 mg/min, max 17 mg/kg; then 1–4 mg/minStable wide-QRS tachycardia
Amiodarone (with a pulse)150 mg over 10 min; then 1 mg/min for 6 hStable wide-QRS tachycardia
Aspirin162–325 mgAcute coronary syndromes
DefibrillationBiphasic per manufacturer (e.g. 120–200 J); monophasic 360 JVF, pVT, polymorphic VT
Synchronized cardioversion100 J narrow / monomorphic VT; 200 J flutter; ≥200 J AFUnstable tachycardia with a pulse

How often do you shock in ACLS? Once per 2-minute cycle, at the rhythm check, and only for VF or pulseless VT. For shock-refractory VF the 2025 Guidelines say the usefulness of vector-change and double sequential defibrillation is not established; neither is part of the standard algorithm the course tests.

2025

What changed in the 2025 ACLS algorithms

The 2025 AHA Guidelines for CPR and Emergency Cardiovascular Care were released on October 22, 2025. For the adult algorithms most of it is refinement: the arrest chart keeps its shape, and the epinephrine, amiodarone, lidocaine and atropine doses are the same as before. The changes below are the ones that turn a once-right answer into a wrong one.

What changed in the 2025 ACLS algorithms
Topic2025Before
Vascular access in arrestIV first; intraosseous if IV fails or is not feasibleIV first, as a weaker suggestion
Ventilation volumeEnough for visible chest rise, about a third to half of an adult bagVisible chest rise, no bag-size cue
Post-ROSC oxygenSpO₂ 90–98%92–98%
Post-ROSC blood pressureMAP at least 65 mm HgSBP and MAP floors
Temperature controlOne target, 32–37.5 °C, held at least 36 h if not following commandsAt least 24 h (2020)
After ROSC imagingHead-to-pelvis CT and point-of-care ultrasound may be reasonableNot on the chart
AF cardioversionAt least 200 J; flutter 200 JDevice-specific, no number
Tachycardia chartSotalol removed; SVT renamed narrow-complex tachycardiaSotalol listed
ACS chartLBBB no longer a definite STEMI sign; fentanyl, enoxaparin, fondaparinux, ACE inhibitors addedLBBB counted; clopidogrel named; morphine only
Stroke chartTenecteplase added beside alteplaseAlteplase only
Chain of survivalOne chain for adults and children, ending in recovery and survivorshipSeparate in- and out-of-hospital chains

The 2025 set also adds charts for cardiac arrest in pregnancy (delivery within 5 minutes of arrest as the goal) and for patients with a ventricular assist device. Neither is a core Megacode case, but both can appear as a written question.

Study

How to memorize the ACLS algorithms

  1. 01Learn the splitting questions

    Shockable or not? Pulse or not? Unstable or not? Wide or narrow? Following commands or not? Five questions carry all six charts.

  2. 02Draw each chart from memory

    Blank paper, one chart a day, then compare with the flowcharts above. The box you forget is the one to tab in the manual.

  3. 03Say it as orders

    The Megacode wants the chart spoken to a team: “Charging to 200, everyone clear, shock.” Run one case aloud every evening.

  4. 04Drill the deck above by chip

    Two chips, arrest and brady/tachy, 12 cards each. Redo the chip you scored lower on the next day.

  5. 05Test the whole spread

    Then take the 60-card practice test or the practice questions by topic; the Study guide sets the order for the rest of the course.

The six charts in five lines

  • Arrest: one shock, 2 minutes of CPR, rhythm check; epinephrine early in asystole/PEA, after the second shock in VF/pVT.
  • After ROSC: SpO₂ 90–98%, PaCO₂ 35–45, MAP ≥65, temperature control for 36 hours if not following commands.
  • Brady: symptoms decide; atropine 1 mg, then pacing or an infusion.
  • Tachy: unstable means synchronized cardioversion; stable means wide-or-narrow, then drugs.
  • ACS and stroke: a 12-lead in 10 minutes; a scan before any clot-busting decision.

FAQ

Questions people ask

What are the algorithms for ACLS?

Six core charts: adult cardiac arrest (VF/pVT and asystole/PEA), post-cardiac arrest care, bradycardia with a pulse, tachycardia with a pulse, acute coronary syndromes and suspected stroke. The 2025 set adds cardiac arrest in pregnancy and a ventricular assist device chart.

What are the most current ACLS algorithms?

The ones built on the 2025 AHA Guidelines for CPR and Emergency Cardiovascular Care, released on October 22, 2025. The ACLS Provider Course was updated to the 2025 Guidelines when they were released, and courses moved to the new materials by March 1, 2026.

Are there new ACLS guidelines for 2026?

No new set. The 2025 Guidelines are current through 2026; what changed in 2026 is that classes switched to the 2025 course materials by March 1, 2026. The list of 2025 changes shows what is new.

How often do you shock in ACLS?

Once per 2-minute CPR cycle, at the rhythm check, and only for VF or pulseless VT. No stacked shocks, and compressions restart straight after each one.

What are the shockable rhythms in ACLS?

Ventricular fibrillation and pulseless ventricular tachycardia (polymorphic VT without a pulse is treated as VF). Asystole and PEA are not shockable.

How do you memorize the ACLS algorithms?

Learn the five splitting questions (shockable, pulse, stable, wide, following commands), draw one chart a day from memory, and say it as team-leader orders. Then drill the deck on this page by chip.

What is the difference between ACLS and BLS?

BLS is compressions, breaths and the AED. ACLS builds on it with rhythm reading, drugs, manual defibrillation, airways and team leading; BLS provider skills are expected before you start.

What is the most current ACLS manual?

The ACLS Provider Manual written to the 2025 Guidelines. Older 2020 manuals still circulate; your Training Center tells you which edition your class uses.

One more cycle, then rest

The exam asks for the next right step, one at a time. Practice exactly that: one card, one decision.